Prolicell Goldstem Microvesicle Exosome

Suppresses UV-induced inflammation on the skin.

Prolongs the life of cells by suppressing the effects of senescence.

Repairs environmental DNA damage by increasing the synthesis of related genes.

Reduces melanin formation and reduces skin spots by suppressing tyrosinase activity.

Inhibits lipid peroxidation; maintains organelle and cell integrity.

Plant Extracellular vesicles (P-EVs), Microvesicles / Exosomes

Similar to mammalian cells EVs, are membranous vesicles released by the plant cells into the extracellular space with key roles in intercellular communication. Exosomes can bind to targeted cells with membrane receptors, use the endocytosis pathway to release content; In other words, it can fuse with the plasma membrane. It is known that exosomes not only contain proteins and lipids, but also carry some non coding RNAs and other regulatory nucleic acids as cargo. It carries the cargo within the organism from one cell to another in order to ensure intercellular communication. It has been reported that they generally carry siRNA, miRNA, snoRNA, snRNA and thus contribute to the regulation of gene expression. It has been shown that miRNAs are carried in a stable state without undergoing any degradation (separation of a complex compound into its components) by means of exosomes and they perform their functions by playing an active role in the recipient cells

Proliferation of PlantCells

Plant stem cell technology is based on the principle of controlled reproduction of totipotent plant cells under sterile laboratory conditions and obtaining plant components specific to stem (undifferentiated) cells. When plant tissues are mechanically damaged, they form clumps of cells called callus in order to repair the damage. Callus cells are totipotent and have the ability to transform into all cells and organs of the plant and even to form a new plant. For this reason, they are called stem cells. Plant stem cells have new cell generation and cell renewal activity due to their totipotent properties. Plant stem cells show their cell renewal stimulating activity not only on plants but also on human skin cells. These properties enable plant stem cells to be an effective cosmetic active ingredient

Harvesting of cells and separation of media and the plant cells

When the amplification of the stem cells done, we separate the cells from the media and keep the cells for a while for the next step s has been done in optimized conditions.

Then we are ready for Isolation of Extracellular vesicles (exosomes microsomes) from the supernatant of the liquid part of culture media

Percentage of use 2-5%